In our latest question and also answer, the pharmacist discusses even if it is or not it is for sure to take NyQuil and azithromycin (Z-Pak) together.

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TJS asked

I started with my an initial dose of Azithromycin today, two 250mg approximately 6hours ago. Can I take it Nyquil tonight before bed.


There room no drug interactions between azithromycin (Z-pak)and Nyquil (acetaminophen, dextromethorphan, and also doxylamine). They have the right to be safely take away together. Below, we willdiscuss an ext about the two medications.

Information about TheZ-Pak

A Z-pak consists of six tablets that azithromycin 250 mg.Usually 2 tablets room prescribed top top the very first day the therapy, followed by onetablet because that the complying with four days.

Azithromycinis a macrolide antibiotic that can treat a selection of epidemic includingbronchitis, sinus infections, ear infections, skin infections, sexuallytransmitted infections, and also more. Azithromycin can cover several varieties ofbacteria, however is not effective intreating the flu, the usual cold, or various other viral infections.

Like many antibiotics, azithromycin may reason diarrhea,nausea, vomiting, and abdominal pain. Macrolides are much more likely to cause thesetypes of next effects, however azithromycin is just one of the more tolerable medicine inthe class. An additional concern through azithromycin is that it can reason QTprolongation in patients with a past medical background related come the heart. Druginteractions can likewise be a problem so always check each new medication prior tostarting a new therapy.

Information AboutNyquil

Nyquil comes in avariety that formulations and also contains several different ingredients. Nyquil Cold& Flu includes the following:

Acetaminophen (pain relief, fever reducer)Dextromethorphan (cough suppressant)Doxylamine (antihistamine)

Acetaminophen is one analgesic that have the right to be taken for a widevariety that acute and also chronic pains ailments. Acetaminophen has a half-life of2-3 hours. Paracetamol gets took in at 85-98% and also reaches peak concentrations within 30-60 minutes.Typically, acetaminophen deserve to startworking within 15 minutes. Acetaminophen deserve to have negative impacts top top theliver, especially at higher doses for an extended duration of time.

Dextromethorphan (commonly described as DM ~ above manyover-the-counter products) is a coughsuppressant that to reduce the advice to cough. The is best to preventbothersome dry sneeze or a sneeze that doesn’t involve mucus from the lowerrespiratory system.

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Doxylamine is a first-generation antihistamine the is morelikely to cause sedation and drowsinessas contrasted to second-generation antihistamines (i.e. Loratadine, cetirizine). Otherfirst-generation antihistamines include Benadryl (diphenhydramine), Dramamine(dimenhydrinate), Chlor-Trimeton (chlorpheniramine), Tavist (clemastine), andPhenergan (promethazine), among others.