In our recent question and also answer, the pharmacist discusses the usage of Claritin (Loratadine) and also Allegra (fexofenadine) together.

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John asked

I to be still having some major problems through Allergies. Have the right to I perform Claritin and also Allegra in ~ the exact same time?


Typically, it is no recommended to usage loratadine(Claritin) and also fexofenadine (Allegra) at the same time. Both medications are second-generationantihistamines offered for allergy relief. Acquisition them with each other would not provide much included benefit,but could lead to side impacts such as drowsiness.

Flonase as An Alternative

Another option, next to taking Claritin and also Allegra together, would be to move or include fluticasone(Flonase) sleep spray. Flonase was authorized by the FDA in 1990, however has onlybeen accessible over-the-counter because 2014. Flonase is a type of steroid thatblocks inflammation, itching, and congestion.

According to the Flonase website, it has some benefits over Claritin includingworking better for sleep congestion. Flonase can be provided once daily with 1 or 2sprays right into each nose or may be used as needed instead of every day.

Zyrtec together An Alternative

Another antihistamine that might be tried instead is cetirizine(Zyrtec). In some patients, Zyrtec maywork better, however, it additionally may additionally cause drowsiness. Zyrtec, Claritin,and Allegra are second-generation antihistamines and also are still much less likely tocause drowsiness 보다 first-generation antihistamines such as Benadryl(diphenhydramine). This is due to the fact that first-generation antihistamines overcome theblood-brain barrier, conversely, the second-generation antihistamines typically donot.

How Antihistamines Work

Antihistamines bind to histamine receptors that are found inthe nose, lungs, eyes, and also skin there is no activating the histamine response. Bybinding and transforming the form of the histamine receptor, antihistaminesinhibit histamine native binding and creating the response. Histamine create animmune solution to basically attempt to eliminate the offensive allergen.

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Histamine have the right to be prompted by a range of points includingpollen, dust, and also pet dander. Some human being are an ext sensitive come this responseand may not also know what triggers their allergies. Antihistamines are usefulin preventing the immune cascade so usual in human being suffering indigenous allergies.


To conclude, the is no recommended to take it both Claritin andAllegra together due to the possibility of drowsiness there is no additionalbenefit. An additional antihistamine that might be considered is Zyrtec, yet mayslightly increase the chance of drowsiness. Finally, Flonase nasal spray might beanother alternative to provide another device of action against allergies.