Medically the evaluation by Femi Aremu, PharmD — written by college of Illinois — updated on march 3, 2021
Zolpidem oral tablets are easily accessible as both generic and brand-name drugs. Brand names: Ambien (immediate-release tablet), Ambien CR (extended-release tablet), Edluar (sublingual tablet), Intermezzo (sublingual tablet).Zolpidem also comes as an dental spray.

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Zolpidem dental tablets are used to law insomnia (trouble sleeping). They can assist you autumn asleep or stay asleep.

Zolpidem is a prescription medicine that comes as an oral tablet computer and an oral spray.

The oral tablet comes in three forms: immediate-release, extended-release, and sublingual. The immediate-release kind releases the drug into your body ideal away. The extended-release type releases the drug into your human body slowly. The sublingual tablet dissolves under your tongue.

These forms are accessible as the following brand-name drugs:

Ambien (immediate-release tablet)Ambien CR (extended-release tablet)Edluar (sublingual tablet)

All creates of zolpidem oral tablets are also accessible as share drugs. Generic medicine usually price less than the brand-name version. In some cases, they may not be easily accessible in all toughness or forms as the brand-name drug.

Why it’s used

Zolpidem oral tablets are offered to act insomnia. Insomnia causes trouble falling asleep or staying asleep.

The immediate-release tablets and also Edluar sublingual tablet computers are supplied if you have trouble fall asleep. The extended-release tablets are supplied if you have actually trouble falling sleep or staying asleep.

The low-dose (1.75-mg and also 3.5-mg) sublingual tablets are supplied when you wake up in the center of the night and have trouble falling back to sleep.

How it works

Zolpidem belongs to a course of drugs called hypnotics. A course of drugs is a team of drugs that job-related in a similar way. These drugs are often used to treat similar conditions.

Zolpidem boosts the task of GABA. GABA is a chemistry in your body that causes sleepiness. Increasing its task helps you autumn asleep.


Zolpidem can cause mild or serious side effects. The adhering to list has some that the key side results that may occur while taking zolpidem. This perform does not include all feasible side effects.

For more information on the possible side impacts of zolpidem, or tips on exactly how to address a troubling next effect, talk through your physician or pharmacist.

More common side effects

The much more common side impacts of zolpidem deserve to include:

headachedrowsinessdizzinessdiarrheadry mouthchest painpalpitations (fast, strong, or irregular heart rate, or feeling like your heart is skip a beat)grogginesslightheadednessmuscle pain

If these impacts are mild, they may go far within a few days or a pair of weeks. If they’re more severe or don’t go away, talk v your physician or pharmacist.

Serious side effects

Call your physician right far if you have actually serious side effects. Contact 911 if her symptoms feel life threaten or if you think you’re having actually a clinical emergency. Significant side effects and also their symptoms can incorporate the following:

Allergic reactions. Symptoms deserve to include: ede of her tongue or facetrouble breathingNew or worse symptoms of depression. Symptoms can include: thoughts of suicide or the harming yourselfloss of interest in activities you normally enjoyfeelings of guilt or worthlessnesslack the energytrouble thinking or concentratingweight loss or load gainAbnormal think or behaviors. Symptoms can include: agitationbeing much more outgoing than normalthinking things aren’t actual or that you’re watching you yourself from exterior of your bodyhallucinations (seeing or hearing points that no there)Doing tasks while you’re asleep and having no memory of the event. These can include: drivingpreparing and also eating foodtalking top top the phonehaving sexTrouble breathing. Symptoms can include: slowed breathingshallow breathingtirednessdecreased oxygen in your bloodAmnesia (memory loss)Hallucinations (seeing or hearing something the isn’t there)

Zolpidem oral tablet can interact with several various other medications. Various interactions can reason different effects. Because that instance, some have the right to interfere with how well a medicine works, while rather can cause increased side effects.

Below is a perform of medications that can connect with zolpidem. This list does no contain all drugs the may connect with zolpidem.

Before taking zolpidem, be sure to tell her doctor and also pharmacist around all prescription, over-the-counter, and also other medicine you take. Also tell them around any vitamins, herbs, and also supplements you use. Sharing this details can aid you protect against potential interactions.

If you have actually questions around drug interactions the may affect you, questioning your doctor or pharmacist.

Increased side results from both zolpidem and other drugs

Taking zolpidem with specific medications raises your danger for side effects. This is because zolpidem and also these other medicines can reason the same side effects. As a result, this side impacts can be increased. Examples of this drugs include:

Drugs the decrease her alertness such together imipramine and chlorpromazine. If you take any of these medications with zolpidem, you might have more sedation and also drowsiness.

Increased side results from zolpidem

Taking zolpidem with certain medications raises your risk for side impacts from zolpidem. This is since the lot of zolpidem in your body might be increased. Instances of this drugs include:

Antibiotics such together clarithromycin and also erythromycinDrugs used to treat fungal infections, such together ketoconazole, itraconazole, and voriconazoleRitonavir and atazanavir

Interactions that have the right to make your drugs less effective

When zolpidem is used with certain drugs, it may not work also to treat your condition. This is because the amount of zolpidem in your body might be decreased. Instances of these drugs include:

Antibiotics such together rifampin, rifabutin, and rifapentineAnticonvulsant drugs such as carbamazepine, phenobarbital, and also phenytoinSt. John’s wort

The zolpidem dosage your doctor prescribes will count on several factors. These include:

the type of insomnia you’re using zolpidem come treatyour age or sexthe type of zolpidem girlfriend takeother medical problems you might have, such as liver damage

Typically, your medical professional will start you top top a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll eventually prescribe the smallest dosage that gives the preferred effect.

The adhering to information defines dosages the are typically used or recommended. However, be sure to take the dosage your physician prescribes because that you. Your physician will determine the ideal dosage to suit your needs.

Forms and strengths

Generic: Zolpidem

Form: immediate-release dental tabletStrengths: 5 mg, 10 mgForm: extended-release oral tabletStrengths: 6.25 mg, 12.5 mgForm: sublingual tabletStrengths: 1.75 mg, 3.5 mg, 5 mg, 10 mg

Brand: Ambien

Form: immediate-release oral tabletStrengths: 5 mg, 10 mg

Brand: Ambien CR

Form: extended-release dental tabletStrengths: 6.25 mg, 12.5 mg

Brand: Edluar

Form: sublingual tabletStrengths: 5 mg, 10 mg

Dosage for insomnia v trouble fallout’s asleep

Adult dosage (ages 18–64 years)

Ambien, Edluar, and generic formulations:

Starting dosage: 5 mg for women and 5 mg or 10 mg because that men, take away right prior to bedtime. You need to only take it a sheep if you have actually at least 7–8 hours prior to you have to wake up.Dosage increases: Your medical professional may boost your dosage to 10 mg per day if the 5 mg dose is not effective.Maximum dosage: 10 mg as soon as per work taken right prior to bedtime.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children. It do not do it be provided in people younger than 18 years.

Senior dosage (ages 65 years and older)

The liver the an larger adult may not work and it offered to. This can cause your human body to procedure drugs an ext slowly. Together a result, an ext of a drug stays in her body for a longer time. This raises your danger for side effects. Your doctor might start girlfriend on a lower dosage or a various treatment schedule. This can help keep level of this medicine from structure up too much in her body.

Ambien, Edluar, and generic formulations: 5 mg as soon as per day taken right prior to bedtime.

Special dosage considerations for people with liver disease

Ambien, Edluar, and generic formulations: 5 mg once per job taken right before bedtime for world with mild to moderate liver disease. Prevent this medicine if you have severe liver disease.

Dosage for problem falling or remaining asleep

Adult dosage (ages 18–64 years)

Ambien CR and generic extended-release oral tablets only:

Starting dosage: 6.25 mg for women and also 6.25 mg or 12.5 mg because that men, bring away right prior to bedtime. Take it it only when you have actually at least 7–8 hours before you must wake up.Dosage increases: Your physician may boost your dosage to 12.5 mg every day if the 6.25 mg sheep is not effective.Maximum dosage: 12.5 mg as soon as per day taken right before bedtime.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be supplied in human being younger than 18 years.

Senior dosage (ages 65 years and also older)

The liver that an larger adult might not work as well as it supplied to. This can reason your body to procedure drugs much more slowly. As a result, more of a drug stays in your body because that a longer time. This raises your threat for side effects. Her doctor might start girlfriend on a lower dosage or a different treatment schedule. This can help keep level of this drug from building up too much in your body.

Ambien CR and generic extended-release oral tablets only: 6.25 mg as soon as per work taken right before bedtime.

Special dosage considerations for world with liver disease

Ambien CR and generic extended-release dental tablets only: 6.25 mg as soon as per job taken right before bedtime for human being with mild come moderate liver disease. Avoid this medicine if you have severe liver disease.

Dosage for trouble falling asleep after waking

Adult dosage (ages 18–64 years)

Generic low-dose sublingual tablets:

Starting dosage: 1.75 mg for women and also 3.5 mg for men, taken as soon as per night together needed. Take this medicine only as soon as you have actually trouble falling earlier to sleep after waking in the center of the night. Also, take this drug only once you have at the very least 4 hours before you must wake up.Dosage increases: If you’re a man and also were began on the 1.75-mg dosage, your doctor may increase your dosage to 3.5 mg every day.Maximum dosage: 1.75 mg per day because that women and also 3.5 mg every day because that men.

Child dosage (ages 0–17 years)

This medication hasn’t to be studied in children. It shouldn’t be supplied in civilization younger than 18 years.

Senior dosage (ages 65 years and older)

The liver that an enlarge adult may not work as well as it provided to. This can cause your body to process drugs much more slowly. As a result, more of a drug stays in her body for a much longer time. This raises your danger for side effects. Your doctor may start friend on a lower dosage or a various treatment schedule. This can assist keep levels of this drug from building up too much in her body.

Generic low-dose sublingual tablet: 1.75 mg taken as soon as per night only as needed. Take it when you have trouble falling ago to sleep after waking in the center of the night. Also, just take this drug when you have at the very least 4 hrs left before you have to wake up.

Special dosage considerations for people with liver disease

Generic low-dose sublingual tablet: 1.75 mg taken as soon as per night together needed. Only take it once you have trouble falling earlier to sleep after ~ waking in the middle of the night. Also, just take this drug once you have at the very least 4 hrs left before you must wake up.

Zolpidem oral tablet comes with number of warnings.

Decreased awareness and reaction time warning

If you take zolpidem and also don’t obtain a complete night’s sleep, you may have diminished awareness and also slower reaction time the next day. This may reason trouble driving. Friend shouldn’t journey or carry out other activities that require alertness if you take it this drug and also don’t obtain a full night’s sleep.

If you’re acquisition generic low-dose sublingual tablets, friend shouldn’t journey or do tasks that call for alertness without obtaining at the very least 4 much more hours the sleep after acquisition it.

Abnormal actions warning

This drug may cause changes in behavior, together as boosted agitation. You might act differently. You may act more outgoing, hallucinate (see or hear things that no real), or feel like you’re watching you yourself from outside of your body. You likewise may sleep-drive or perform other activities in her sleep the you can not remember later.

Tell your doctor if any of this happens to you.

Withdrawal results warning

Don’t stop taking this drug without talking v your doctor. If did you do it been acquisition this medication for a while and also stop taking it suddenly, girlfriend may have withdrawal.

Symptoms can encompass muscle cramps, vomiting, sweating, flushing (reddening and also warming of your skin), and also emotional changes. This can incorporate feelings that nervousness, scare attacks, and also uncontrollable crying.

Allergy warning

Zolpidem can reason a severe allergic reaction. Symptoms can include:

trouble breathingswelling of your neck or tongue

If you have an allergy reaction, speak to your medical professional or regional poison control center right away. If your symptoms room severe, contact 911 or walk to the nearest emergency room.

Don’t take it this drug again if you’ve ever before had an allergy reaction to it. taking it again might be deadly (cause death).

Food communication warning

Eating food with zolpidem might make the drug take longer to work. You have to take this drug on an north stomach.

Alcohol interaction warning

Drinking alcohol can increase your hazard for sedation and also drowsiness native zolpidem. Girlfriend shouldn’t take this drug on nights once you drink alcohol. If girlfriend drink alcohol, talk v your doctor. You may need to be monitored an ext closely for side effects.

Warnings for civilization with specific health conditions

For world with depression: This drug might make her symptoms the depression worse. Questioning your medical professional if this medicine is for sure for you.

For people with myasthenia gravis: This drug might slow her breathing or do it shallow. This can decrease the lot of oxygen in your blood. If you have myasthenia gravis, you may currently have reduced oxygen levels. Ask your doctor if this medicine is for sure for you.

For world with sleep apnea: This drug might slow her breathing or do it shallow. This have the right to decrease the amount of oxygen in your blood. If you have actually sleep apnea, you may currently have reduced oxygen levels. Questioning your physician if this drug is safe for you.

For civilization with liver disease: If you have liver troubles or a background of liver disease, you might not it is in able to procedure this medicine well. This may increase the level of the medicine in her body and also cause more side effects. That may additionally cause a serious problem called hepatic encephalopathy. With this condition, the poor duty of her liver reasons problems with the means your brain works. Symptoms can incorporate being confused, forgetting things, and also slurring your speech. If you have severe liver damage, you have to not usage zolpidem.

Warnings for other groups

For pregnant women: over there haven’t been sufficient studies done in people to be certain how the drug might influence the fetus. Study in animals has shown an unfavorable effects come the fetus as soon as the mother takes zolpidem. But animal studies don’t always predict how humans would certainly respond.

Studies have shown that as soon as mothers take it this medicine late in their third trimester, your newborns have the right to have slowed breathing and excessive sleepiness. Your physician will monitor your newborn carefully if exposure come zolpidem occurred during her pregnancy.

This drug should only be provided if the potential benefit justifies the potential risk. Talk with your medical professional if you pregnant or plan to end up being pregnant. And also call your doctor right away if you become pregnant while acquisition this drug.

For women who space breastfeeding: Zolpidem might pass into breast milk and also cause side results in a boy who is breastfed. Talk through your doctor around breastfeeding your child. You might need to decision whether to avoid breastfeeding or avoid taking this medication.

For seniors: The liver the an enlarge adult might not work and also it provided to. This can reason your human body to process drugs more slowly. As a result, much more of a drug stays in her body for a much longer time. This raises your threat for side effects, such together sedation and also decreased alertness. You may also be an ext sensitive to this effects. If you’re over the period of 65 years, your physician may provide you a reduced dosage of this drug.

For children: This medicine hasn’t been studied in children. It shouldn’t be offered in world younger 보다 18 years.


Zolpidem oral tablet is offered for short-term treatment. That comes through serious risks if you don’t take it together prescribed.

If you prevent taking the drug all of sudden or don’t take it at all: If friend don’t take it this drug, you’ll still have actually trouble falling or remaining asleep. If did you do it been acquisition this medication because that a while and stop taking it suddenly, girlfriend may have actually signs that withdrawal.

Withdrawal symptoms can include muscle cramps, vomiting, sweating, flushing (reddening and warming of your skin), and also emotional changes. This can incorporate nervousness, scare attacks, or uncontrollable crying. Never stop taking this medicine without talking to your doctor.

If you miss doses or don’t take the drug on schedule: her medication might not work as well or may stop working completely.

If you take as well much: You can have dangerous level of the medicine in her body. Symptoms of one overdose the this drug deserve to include:

extreme drowsinessloss that consciousnesscomatrouble breathing

If friend think you’ve taken too much of this drug, call your medical professional or look for guidance native the American association of Poison manage Centers in ~ 800-222-1222 or through their digital tool. But if her symptoms are severe, call 911 or go to the nearest emergency room best away.

What to do if you miss a dose:

For immediate-release tablets, extended-release tablets, and also Edluar: Take your dose as soon as you remember, but only if you have 7–8 hrs left prior to you have to wake up.For share low-dose sublingual tablets: nothing take her dose if you have less than 4 hrs left before you must wake up.

How come tell if the drug is working: friend should have actually an easier time fall asleep and also staying asleep.


Keep these considerations in mind if your medical professional prescribes zolpidem oral tablet for you.

General

You have to not take this drug v food. Taking this drug with food might make the take much longer to work.Take the immediate-release tablets, extended-release tablets, and Edluar right prior to bedtime. Only take these creates when you have actually 7–8 hours to sleep before you need to wake up.Only take it Ambien together a single dose each night. Do not take it a second time throughout the same night.Take share low-dose sublingual tablets once you wake up in the night. Take it it just if you have actually 4 hrs of sleep left before you must wake up.You can cut or to like the immediate-release tablets. Carry out not cut or to like the extended-release tablets.Store the immediate-release tablets (Ambien) and also sublingual tablet computers (Edluar) at room temperature. Store them between 68°F and 77°F (20°C and also 25°C).

Storage

Store the extended-release tablets (Ambien CR) in between 59°F and also 77°F (15°C and 25°C). Store them away from light.Don’t store this medicine in moist or wet areas, such together bathrooms.

Refills

A prescription because that this medication is refillable. Due to the fact that zolpidem is a Schedule IV managed substance, her doctor might refill this medication up to five times in 6 months. Your medical professional will compose the variety of refills authorized on your prescription.

Travel

When traveling with your medication:

Always bring your medication through you. When flying, never ever put it into a checked bag. Store it in her carry-on bag.Don’t worry around airport X-ray machines. They can not hurt her medication.You may need to present airport staff the pharmacy label for your medication. Always carry the initial prescription-labeled container with you.Don’t put this medicine in her car’s gloves compartment or leaving it in the car. Be sure to protect against doing this when the weather is very hot or very cold.

Clinical monitoring

You and also your doctor have to monitor certain health issues during your treatment. This can help make sure you remain safe while you take this drug. These problems include:

Mental health and behavioral problems. You and also your doctor have to watch for any kind of changes in her behavior and also mood. This drug deserve to cause new mental health and also behavior problems. That may likewise worsen troubles you currently have.Liver function. Your physician will monitor her liver duty during her treatment with this drug. If your liver isn’t functioning well, your physician may lower your dosage the this drug.

Availability

Not every pharmacy share this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Insurance

Many insurance service providers require a former authorization because that this drug. This means your doctor may need to get approval from your insurance company before her insurance agency will pay for the prescription.


There are other drugs easily accessible to treat your condition. Some might be much better suited for you 보다 others. Talk through your doctor around other drug alternatives that might work for you.

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Disclaimer: znjke.com has made every effort to make certain that all information is factually correct, comprehensive, and also up come date. However, this post should not be used as a substitute for the knowledge and expertise of a licensed medical care professional. You should constantly consult your medical professional or other health care professional before taking any medication. The drug information contained herein is subject to adjust and is not intended to cover all possible uses, directions, precautions, warnings, medicine interactions, allergic reactions, or adverse effects. The absence of warnings or other info for a offered drug does not suggest that the medicine or drug mix is safe, effective, or appropriate for every patients or all particular uses.