Written by Rachael Link, MS, RD top top February 10, 2021 — median reviewed by approve Tinsley, PhD, Nutrition

Acid reflux, likewise known as gastroesophageal reflux an illness (GERD), is a typical digestive issue.

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It’s associated with a range of next effects, including heartburn, nausea, belching, and stomach pain (1).

In enhancement to medicines like antacids and also proton pump inhibitors, many treatments for mountain reflux show off making diet or lifestyle changes.

Many vitamins, herbs, and supplements may additionally help administer relief native symptoms.

Here room 6 supplements that might be beneficial for the therapy of mountain reflux.

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1. Betaine HCl through pepsin
Betaine hydrochloride (HCl) is a compound supplied to increase stomach acid (2).

Low level of stomach acid might slow digestion and the absorption of nutrients, and cause a range of side effects, including heartburn, stomach pain, and acid reflux (3).

One research in 6 human being with low levels the stomach acid verified that taking 1500 mg that betaine HCl increased stomach acidity (4).

Betaine hydrochloride is also paired with pepsin in plenty of supplements. Pepsin is a digestive enzyme in stomach acid that division proteins right into smaller units (5).

One 6-week study in 97 human being with indigestion found that taking pepsin merged with amino mountain hydrochloride substantially reduced symptoms favor stomach pain and burning (6).

That said, the U.S. Food and Drug administration (FDA) has concluded yes not at this time enough evidence to certain the efficiency of betaine HCl or pepsin at boosting stomach mountain (7).

Therefore, much more research on even if it is betaine HCl v pepsin may be useful for treating acid reflux is needed.


Some studies suggest that betaine HCl may rise stomach mountain in people with low stomach acid, in order to reducing symptom of acid reflux. Pepsin may also relieve indigestion symptoms, but an ext research is needed.

2. B vitamins

Some research suggests that B vitamins, consisting of folate, riboflavin, and vitamin B6, may aid treat acid reflux.

In fact, one study discovered that increased intake of number of B vitamin was associated with a reduced risk of reflux esophagitis, a condition characterized by inflammation in the esophagus regularly caused by acid reflux (8).

What’s more, higher intakes of folate and also vitamin B6 were linked to a reduced risk of stomach cancer and also a problem called Barrett’s esophagus, both of which space potential symptom of irreversible GERD (8).

Another larger study compared the effectiveness of a complement containing vitamin B6, folic acid, vitamin B12, L-tryptophan, melatonin, betaine, and methionine through an over-the-counter treatment for heartburn (9).

After 40 work of treatment, 100% the those who took the supplement experienced finish relief native heartburn symptoms, compared with simply 65% of those who took the over-the-counter therapy (9).

However, store in mind that B vitamins were simply one component of this supplement, therefore it’s unclear just how much that an effect B vitamins might have had specifically.

Further research study is required to evaluate just how B vitamin may influence acid reflux symptom when used alone.


B vitamins may be linked to a reduced risk of complications caused by acid reflux. They may also relieve heartburn symptoms when paired with other compounds, but much more research is needed.

Melatonin is a hormone that’s mostly responsible because that regulating the sleep-wake cycle (10).

Although it’s generally used to treat insomnia and also improve sleep quality, some researches have discovered that melatonin may also aid in the treatment of acid reflux.

According come one study in 36 people, acquisition melatonin, one of two people alone or with heartburn medication, because that 4–8 weeks lessened symptoms of GERD (11).

Other study has uncovered that low levels the melatonin may additionally be connected with a greater risk of digestive disorders, consisting of peptic ulcers and acid reflux (12).

What’s more, part studies imply that melatonin may help protect versus inflammation the the esophagus, which can prevent long-term health issues linked with GERD, such as Barrett’s esophagus (13, 14).


Some research shows that melatonin might reduce mountain reflux and protect versus long-term health concerns caused by GERD.

Iberogast is one over-the-counter supplement frequently used to treat acid reflux and irritable bowel syndrome (IBS).

It’s do from a blend of herbal extracts, including peppermint, licorice root, and milk thistle fruit.

One testimonial of 12 studies verified that Iberogast is normally well-tolerated and may help reduce symptom of indigestion much more effectively than a placebo (15).

Another examine in 272 people showed the Iberogast significantly improved cradle symptoms, together as upper stomach pain, heartburn, and loss of appetite, in ~ 15 minutes of the first dose (16).

Furthermore, one pet study discovered Iberogast to it is in as reliable as a classic antacid at decreasing stomach acidity. It also hindered fag acidity, which is rise in stomach acid once medicines are stopped (17).


Iberogast is an organic supplement the may help decrease stomach acid and also relieve symptoms of mountain reflux.

Probiotics room a kind of useful bacteria discovered in the digestive tract. Castle play a an essential role in gut health and immune duty (18).

Some research has uncovered that supplementing with probiotics may aid decrease symptoms of acid reflux.

For instance, one testimonial of 13 studies discovered 79% of lock observed the probiotics had valuable effects on symptom of GERD, including diminished regurgitation, lessened heartburn, and less stomach pain and also nausea (19).

In another 12-week study, combining heartburn medication with probiotics lessened the danger of treatment relapse, contrasted with a control group the only obtained heartburn medicine (20).

Plus, one current study uncovered that taking probiotics might reduce the threat of gut flora transforms caused by long-term use of proton pump inhibitors (PPIs) provided to act GERD (21).


Probiotics may help improve symptoms of acid reflux and reduce the hazard of therapy relapse when supplied with heartburn medication. Probiotics may also help prevent alters in the gut flora led to by PPIs.

Ginger, i m sorry is scientifically known as Zingiber officinale, is a tree that’s provided as both a spice and also herbal supplement.

It’s regularly used come soothe stomach upset and treat problems like nausea and indigestion (22).

One small study discovered that taking 3 grams the ginger powder day-to-day for 4 weeks enhanced several symptoms of indigestion, including stomach pain, belching, and also feelings the fullness (23).

Another study uncovered that ginger may speed stomach emptying. Delay stomach emptying can add to symptom of mountain reflux, such as heartburn and also regurgitation (24, 25).

Other research suggests that pairing ginger through other organic extracts, such as perilla and also artichoke leaf, might also administer relief from mountain reflux (26, 27).

That said, spend high amounts of ginger may reason adverse side effects and worsen concerns like heartburn and stomach discomfort, for this reason be certain to just use it together directed (28).

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Ginger may enhance symptoms the indigestion and aid speed stomach emptying. It may likewise decrease acid reflux when paired with other ingredients, such as perilla and also artichoke leaf.